Interazioni tra farmaci
Carbimazole + Rosuvastatin
Gravità: Moderata
Carbimazole and Rosuvastatin: moderate interaction.
Ultimo aggiornamento Fonti: US FDA label
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Sintesi
Carbimazole treats hyperthyroidism and can overshoot into hypothyroidism if the dose is excessive. Hypothyroidism is a recognised risk factor for statin-associated myopathy and rhabdomyolysis, so muscle toxicity from rosuvastatin may be more likely during periods of low thyroid function. The interaction is indirect and depends on thyroid status.
Cosa significa questa interazione in parole semplici
Carbimazole and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbimazole belongs to Endocrine; Rosuvastatin belongs to Cardiovascular.
Perché avviene
Pharmacodynamic and indirect: drug-induced hypothyroidism predisposes to statin myotoxicity. No direct CYP or transporter interaction is expected.
Cosa fare
Check thyroid function before starting or increasing rosuvastatin and aim for euthyroidism. Monitor thyroid function regularly after carbimazole dose changes and adjust carbimazole if TSH rises.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Riferimenti
- Crestor (rosuvastatin calcium) Prescribing Information - Warnings and Precautions: Myopathy and Rhabdomyolysis — FDA Label
- Neo-Mercazole (carbimazole) Summary of Product Characteristics — EMA SmPC
Altre interazioni di Carbimazole
- Carbimazole + Tiratricol Moderata
Altre interazioni di Rosuvastatin
- Atazanavir + Rosuvastatin Maggiore
- Cyclosporine + Rosuvastatin Maggiore
- Cyclosporin + Rosuvastatin Maggiore
- Darolutamide + Rosuvastatin Maggiore
- Dasabuvir + Rosuvastatin Maggiore
- Elbasvir / grazoprevir + Rosuvastatin Maggiore
Domande frequenti
Can I take Carbimazole with Rosuvastatin?
MediHelp rates the interaction as moderate. Carbimazole and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbimazole treats hyperthyroidism and can overshoot into hypothyroidism if the dose is excessive. Hypothyroidism is a recognised risk factor for statin-associated myopathy and rhabdomyolysis, so muscle toxicity from rosuvastatin may be more likely during periods of low thyroid function. The interaction is indirect and depends on thyroid status.
How serious is the interaction between Carbimazole and Rosuvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check thyroid function before starting or increasing rosuvastatin and aim for euthyroidism. Monitor thyroid function regularly after carbimazole dose changes and adjust carbimazole if TSH rises.
What other medicines interact with Carbimazole?
MediHelp also lists interactions of Carbimazole with, for example, Tiratricol. The full list is on the Carbimazole page.
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