Riferimento farmaci
Carbimazole
Carbimazole is a medicine in the class endocrine. It is used for hyperthyroidism.
- Classe del farmaco: Endocrine
- Indicato per: hyperthyroidism
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In breve
- Classe del farmaco
- Endocrine
- Forme farmaceutiche comuni
- compressa
- Dosaggi comuni
- 5 mg, 20 mg
- Interazioni note
- 2 (Moderata: 2)
- Nomi commerciali
- 10
- Paesi e mercati
- 4
Per cosa si usa
Come agisce
Its antithyroid action is due to its conversion to methimazole after absorption. It is used to treat hyperthyroidism and thyrotoxicosis. Carbimazole is an aitithyroid agent that decreases the uptake and concentration of inorganic iodine by thyroid, it also reduces the formation of di-iodotyrosine and thyroxine.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Initial dose is in the range 20 mg to 60 mg, taken as two to three divided doses.
Gravidanza e allattamento
- Gravidanza
- Unsafe Suspected to cause birth defects with 1st-trimester use (scalp, gut and abdominal wall defects). Use effective contraception; in early pregnancy propylthiouracil is usually preferred. If needed later, use the lowest dose and monitor mother, fetus and newborn thyroid.
- Allattamento
- Safe Converted to methimazole, which passes into milk. UK label: do not breastfeed if treatment continues. LactMed and thyroid guidelines: moderate doses are acceptable and do not affect infant thyroid function; monitor infant growth.
Effetti indesiderati segnalati
- Headache
- Nausea
- Angioedema
- Bone marrow depression
- Acute pancreatitis
Chi deve prestare attenzione
- Patients unable to comply with the instructions for use or who cannot be monitored regularly should not be treated with carbimazole.
- Carbimazole tablets should be used with caution in patients with mild-moderate hepatic insufficiency.
- Precaution should be taken in patients with intrathoracic goitre, which may worsen during initial treatment with carbimazole
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Interazioni principali (2)
- Carbimazole + Rosuvastatin Moderate
- Carbimazole + Tiratricol Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
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Altri farmaci della stessa classe
Domande frequenti
What is Carbimazole used for?
Carbimazole is a medicine in the class endocrine. It is used for Hyperthyroidism.
What side effects have been reported with Carbimazole?
Headache, Nausea, Angioedema, Bone marrow depression, Acute pancreatitis.
Can Carbimazole be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Suspected to cause birth defects with 1st-trimester use (scalp, gut and abdominal wall defects). Use effective contraception; in early pregnancy propylthiouracil is usually preferred. If needed later, use the lowest dose and monitor mother, fetus and newborn thyroid. Breastfeeding: Safe. Converted to methimazole, which passes into milk. UK label: do not breastfeed if treatment continues. LactMed and thyroid guidelines: moderate doses are acceptable and do not affect infant thyroid function; monitor infant growth.
What does Carbimazole interact with?
MediHelp lists 2 known interactions for Carbimazole. Moderate: 2. The most serious include Rosuvastatin, Tiratricol.
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