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Interazioni tra farmaci

Cefazolin + Gentamicin

Gravità: Moderata

Cefazolin and Gentamicin: moderate interaction.

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Sintesi

Giving cefazolin with gentamicin may raise the risk of kidney injury, mainly in patients who are elderly, volume-depleted or have existing renal impairment. The aminoglycoside is the principal nephrotoxic and ototoxic agent, and the combination is often used deliberately, for example in endocarditis.

Cosa significa questa interazione in parole semplici

Cefazolin and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Cefazolin belongs to Anti Bacterial; Gentamicin belongs to Anti Bacterial.

Livello di evidenza: Low

Perché avviene

Additive nephrotoxic potential; cephalosporins may modestly add to aminoglycoside tubular injury.

Cosa fare

Monitor serum creatinine and gentamicin levels, keep the patient well hydrated and limit the duration of aminoglycoside therapy. Adjust the doses for renal function.

Cosa chiedere al farmacista

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Cefazolin with Gentamicin?

MediHelp rates the interaction as moderate. Cefazolin and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Giving cefazolin with gentamicin may raise the risk of kidney injury, mainly in patients who are elderly, volume-depleted or have existing renal impairment. The aminoglycoside is the principal nephrotoxic and ototoxic agent, and the combination is often used deliberately, for example in endocarditis.

How serious is the interaction between Cefazolin and Gentamicin?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and gentamicin levels, keep the patient well hydrated and limit the duration of aminoglycoside therapy. Adjust the doses for renal function.

What other medicines interact with Cefazolin?

MediHelp also lists interactions of Cefazolin with, for example, Amikacin, Bcg vaccine live, Cholera vaccine. The full list is on the Cefazolin page.

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