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Interazioni tra farmaci

Amikacin + Cefazolin

Gravità: Moderata

Amikacin and Cefazolin: moderate interaction.

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Sintesi

Amikacin is nephrotoxic and ototoxic, and cephalosporins have been reported to add to renal injury in some cases. Cefazolin has relatively low nephrotoxic potential, but the combination is used together often enough that kidney function needs attention.

Cosa significa questa interazione in parole semplici

Amikacin and Cefazolin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Amikacin belongs to Anti Bacterial; Cefazolin belongs to Anti Bacterial.

Livello di evidenza: Low

Perché avviene

Possible additive renal tubular injury; aminoglycoside toxicity is the dominant contributor.

Cosa fare

Monitor serum creatinine and amikacin levels during therapy. Adjust the amikacin dose to renal function and minimize treatment duration.

Cosa chiedere al farmacista

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Amikacin with Cefazolin?

MediHelp rates the interaction as moderate. Amikacin and Cefazolin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amikacin is nephrotoxic and ototoxic, and cephalosporins have been reported to add to renal injury in some cases. Cefazolin has relatively low nephrotoxic potential, but the combination is used together often enough that kidney function needs attention.

How serious is the interaction between Amikacin and Cefazolin?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and amikacin levels during therapy. Adjust the amikacin dose to renal function and minimize treatment duration.

What other medicines interact with Cefazolin?

MediHelp also lists interactions of Cefazolin with, for example, Bcg vaccine live, Cholera vaccine, Dexamethasone-tobramycin. The full list is on the Cefazolin page.

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