Interazioni tra farmaci
Cefazolin + Sodium picosulfate / magnesium oxide / anhydrous citric acid
Gravità: Moderata
Cefazolin and Sodium picosulfate / magnesium oxide / anhydrous citric acid: moderate interaction.
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Sintesi
Sodium picosulfate is a prodrug that must be converted to its active laxative form by colonic bacteria. Antibiotics that suppress colonic flora may reduce this activation and lead to poorer bowel cleansing before colonoscopy. Cefazolin is given parenterally, so the effect is likely smaller than with oral antibiotics, but labeling advises caution.
Cosa significa questa interazione in parole semplici
Cefazolin and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perché avviene
Antibiotic suppression of colonic bacteria needed to convert sodium picosulfate to its active metabolite.
Cosa fare
Assess bowel preparation adequacy before the procedure and consider extra preparation or rescheduling if cleansing is poor. Where possible, avoid starting antibiotics around the time of the preparation.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Cefazolin
- Amikacin + Cefazolin Moderata
- Bcg vaccine live + Cefazolin Moderata
- Cefazolin + Cholera vaccine Moderata
- Cefazolin + Dexamethasone-tobramycin Moderata
- Cefazolin + Gentamicin Moderata
- Cefazolin + Kanamycin Moderata
Domande frequenti
Can I take Cefazolin with Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates the interaction as moderate. Cefazolin and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium picosulfate is a prodrug that must be converted to its active laxative form by colonic bacteria. Antibiotics that suppress colonic flora may reduce this activation and lead to poorer bowel cleansing before colonoscopy. Cefazolin is given parenterally, so the effect is likely smaller than with oral antibiotics, but labeling advises caution.
How serious is the interaction between Cefazolin and Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess bowel preparation adequacy before the procedure and consider extra preparation or rescheduling if cleansing is poor. Where possible, avoid starting antibiotics around the time of the preparation.
What other medicines interact with Cefazolin?
MediHelp also lists interactions of Cefazolin with, for example, Amikacin, Bcg vaccine live, Cholera vaccine. The full list is on the Cefazolin page.
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