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Interazioni tra farmaci

Cefotetan + Gentamicin

Gravità: Moderata

Cefotetan and Gentamicin: moderate interaction.

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Sintesi

Concurrent use of cephalosporins with aminoglycosides has been associated with increased renal injury in some reports, although the effect is inconsistent for most agents. Risk is greatest in patients with renal impairment, older age or dehydration.

Cosa significa questa interazione in parole semplici

Cefotetan and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Cefotetan belongs to Anti Bacterial; Gentamicin belongs to Anti Bacterial.

Livello di evidenza: Low

Perché avviene

Possible additive proximal tubular injury; mechanism is not firmly established.

Cosa fare

Monitor renal function and gentamicin concentrations, and adjust doses according to creatinine clearance.

Cosa chiedere al farmacista

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Cefotetan with Gentamicin?

MediHelp rates the interaction as moderate. Cefotetan and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use of cephalosporins with aminoglycosides has been associated with increased renal injury in some reports, although the effect is inconsistent for most agents. Risk is greatest in patients with renal impairment, older age or dehydration.

How serious is the interaction between Cefotetan and Gentamicin?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and gentamicin concentrations, and adjust doses according to creatinine clearance.

What other medicines interact with Gentamicin?

MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.

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