Drug interactions
Cefotetan + Gentamicin
Severity: Moderate
Cefotetan and Gentamicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use of cephalosporins with aminoglycosides has been associated with increased renal injury in some reports, although the effect is inconsistent for most agents. Risk is greatest in patients with renal impairment, older age or dehydration.
What this interaction means in plain words
Cefotetan and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefotetan belongs to Anti Bacterial; Gentamicin belongs to Anti Bacterial.
Why it happens
Possible additive proximal tubular injury; mechanism is not firmly established.
What to do
Monitor renal function and gentamicin concentrations, and adjust doses according to creatinine clearance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Other interactions of Cefotetan
- Cefotetan + Dronabinol Contraindicated
- Cefotetan + Warfarin Major
- Amikacin + Cefotetan Moderate
- Argatroban + Cefotetan Moderate
- Cefotetan + Dalteparin Moderate
- Cefotetan + Enoxaparin Moderate
Frequently asked questions
Can I take Cefotetan with Gentamicin?
MediHelp rates the interaction as moderate. Cefotetan and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use of cephalosporins with aminoglycosides has been associated with increased renal injury in some reports, although the effect is inconsistent for most agents. Risk is greatest in patients with renal impairment, older age or dehydration.
How serious is the interaction between Cefotetan and Gentamicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and gentamicin concentrations, and adjust doses according to creatinine clearance.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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