Interazioni tra farmaci
Chloral hydrate + Clobazam
Gravità: Maggiore
Chloral hydrate and Clobazam: major interaction.
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Sintesi
Clobazam is a benzodiazepine, and combining it with chloral hydrate increases sedation and the risk of respiratory depression. Impaired cognition and falls are more likely in older or frail patients.
Cosa significa questa interazione in parole semplici
Chloral hydrate and Clobazam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloral hydrate belongs to Central Nervous System; Clobazam belongs to Central Nervous System.
Perché avviene
Additive CNS depression through enhanced GABAergic inhibition.
Cosa fare
Avoid concurrent use where possible; otherwise use the lowest effective doses and monitor sedation and respiratory function. Caution against alcohol and other depressants.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Controindicata
- Chloral hydrate + Sodium oxybate Controindicata
- Alfentanil + Chloral hydrate Maggiore
- Alprazolam + Chloral hydrate Maggiore
- Amobarbital + Chloral hydrate Maggiore
- Belladonna and opium + Chloral hydrate Maggiore
Altre interazioni di Clobazam
- Amobarbital + Clobazam Maggiore
- Buprenorphine + Clobazam Maggiore
- Butorphanol + Clobazam Maggiore
- Carisoprodol + Clobazam Maggiore
- Clobazam + Clozapine Maggiore
- Clobazam + Codeine Maggiore
Domande frequenti
Can I take Chloral hydrate with Clobazam?
MediHelp rates the interaction as major. Chloral hydrate and Clobazam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clobazam is a benzodiazepine, and combining it with chloral hydrate increases sedation and the risk of respiratory depression. Impaired cognition and falls are more likely in older or frail patients.
How serious is the interaction between Chloral hydrate and Clobazam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible; otherwise use the lowest effective doses and monitor sedation and respiratory function. Caution against alcohol and other depressants.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
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