Interazioni tra farmaci
Clobazam + Clozapine
Gravità: Maggiore
Clobazam and Clozapine: major interaction.
Ultimo aggiornamento
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Sintesi
Both agents depress the CNS, so combining them can cause excessive sedation, and benzodiazepines with clozapine have been associated with respiratory depression and collapse. The risk is highest at initiation or after dose increases.
Cosa significa questa interazione in parole semplici
Clobazam and Clozapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clobazam belongs to Central Nervous System; Clozapine belongs to Central Nervous System.
Perché avviene
Additive CNS and respiratory depression through GABA-A potentiation and clozapine's sedative actions.
Cosa fare
Use the lowest effective doses and titrate slowly, monitoring sedation, blood pressure and respiratory status. Avoid starting both together.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Clozapine
- Clozapine + Deferiprone Controindicata
- Clozapine + Irinotecan Controindicata
- Clozapine + Pimozide Controindicata
- Clozapine + Thioridazine Controindicata
- Acalabrutinib + Clozapine Maggiore
- Adagrasib + Clozapine Maggiore
Altre interazioni di Clobazam
- Amobarbital + Clobazam Maggiore
- Buprenorphine + Clobazam Maggiore
- Butorphanol + Clobazam Maggiore
- Carisoprodol + Clobazam Maggiore
- Chloral hydrate + Clobazam Maggiore
- Clobazam + Codeine Maggiore
Domande frequenti
Can I take Clobazam with Clozapine?
MediHelp rates the interaction as major. Clobazam and Clozapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents depress the CNS, so combining them can cause excessive sedation, and benzodiazepines with clozapine have been associated with respiratory depression and collapse. The risk is highest at initiation or after dose increases.
How serious is the interaction between Clobazam and Clozapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and titrate slowly, monitoring sedation, blood pressure and respiratory status. Avoid starting both together.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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