Interazioni tra farmaci
Chloroquine + Cisapride
Gravità: Controindicata
Chloroquine and Cisapride: contraindicated interaction.
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Sintesi
Both drugs can prolong the QT interval. Used together they raise the risk of torsades de pointes and sudden cardiac death. Cisapride is already restricted because of this risk.
Cosa significa questa interazione in parole semplici
Chloroquine and Cisapride are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Chloroquine belongs to Anti Parasitic; Cisapride belongs to Gastrointestinal Tract.
Perché avviene
Additive blockade of cardiac hERG potassium channels causing delayed repolarization and QT prolongation.
Cosa fare
Avoid the combination; use a non-QT-prolonging prokinetic or antimalarial alternative. If unavoidable, obtain a baseline ECG and correct potassium and magnesium before and during therapy.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Cisapride
- Apomorphine + Cisapride Controindicata
- Artemether + Cisapride Controindicata
- Azithromycin + Cisapride Controindicata
- Ceritinib + Cisapride Controindicata
- Cisapride + Citalopram Controindicata
- Cisapride + Clarithromycin Controindicata
Altre interazioni di Chloroquine
- Chloroquine + Dofetilide Controindicata
- Chloroquine + Dronedarone Controindicata
- Chloroquine + Droperidol Controindicata
- Chloroquine + Panobinostat Controindicata
- Chloroquine + Pimozide Controindicata
- Chloroquine + Quinidine Controindicata
Domande frequenti
Can I take Chloroquine with Cisapride?
MediHelp rates the interaction as contraindicated. Chloroquine and Cisapride are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs can prolong the QT interval. Used together they raise the risk of torsades de pointes and sudden cardiac death. Cisapride is already restricted because of this risk.
How serious is the interaction between Chloroquine and Cisapride?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use a non-QT-prolonging prokinetic or antimalarial alternative. If unavoidable, obtain a baseline ECG and correct potassium and magnesium before and during therapy.
What other medicines interact with Cisapride?
MediHelp also lists interactions of Cisapride with, for example, Apomorphine, Artemether, Azithromycin. The full list is on the Cisapride page.
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