Interazioni tra farmaci
Chloroquine + Panobinostat
Gravità: Controindicata
Chloroquine and Panobinostat: contraindicated interaction.
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Sintesi
Panobinostat significantly prolongs the QT interval and its labeling advises against use with other QT-prolonging drugs such as chloroquine. Combined use increases the risk of torsades de pointes and sudden cardiac death.
Cosa significa questa interazione in parole semplici
Chloroquine and Panobinostat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Chloroquine belongs to Anti Parasitic; Panobinostat belongs to Oncology.
Perché avviene
Additive prolongation of cardiac repolarization (QTc).
Cosa fare
Do not combine; use a non-QT-prolonging alternative to chloroquine during panobinostat therapy.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Chloroquine
- Chloroquine + Cisapride Controindicata
- Chloroquine + Dofetilide Controindicata
- Chloroquine + Dronedarone Controindicata
- Chloroquine + Droperidol Controindicata
- Chloroquine + Pimozide Controindicata
- Chloroquine + Quinidine Controindicata
Altre interazioni di Panobinostat
- Amiodarone + Panobinostat Controindicata
- Anagrelide + Panobinostat Controindicata
- Chlorpromazine + Panobinostat Controindicata
- Dronedarone + Panobinostat Controindicata
- Haloperidol + Panobinostat Controindicata
- Moxifloxacin + Panobinostat Controindicata
Domande frequenti
Can I take Chloroquine with Panobinostat?
MediHelp rates the interaction as contraindicated. Chloroquine and Panobinostat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Panobinostat significantly prolongs the QT interval and its labeling advises against use with other QT-prolonging drugs such as chloroquine. Combined use increases the risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Chloroquine and Panobinostat?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use a non-QT-prolonging alternative to chloroquine during panobinostat therapy.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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