Interazioni tra farmaci
Chlorpromazine + Glycopyrrolate
Gravità: Moderata
Chlorpromazine and Glycopyrrolate: moderate interaction.
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Sintesi
Chlorpromazine has anticholinergic properties that add to those of glycopyrrolate. This may cause dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion, and in severe cases reduced gut motility or ileus.
Cosa significa questa interazione in parole semplici
Chlorpromazine and Glycopyrrolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Glycopyrrolate belongs to Respiratory.
Perché avviene
Additive antimuscarinic (anticholinergic) pharmacodynamic effects.
Cosa fare
Monitor for anticholinergic adverse effects, especially in older patients, and for constipation or urinary retention. Reduce the dose of one agent or choose an alternative if symptoms become troublesome.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Chlorpromazine
- Chlorpromazine + Dofetilide Controindicata
- Chlorpromazine + Dronedarone Controindicata
- Chlorpromazine + Droperidol Controindicata
- Chlorpromazine + Ibutilide Controindicata
- Chlorpromazine + Metrizamide Controindicata
- Chlorpromazine + Panobinostat Controindicata
Altre interazioni di Glycopyrrolate
- Glycopyrrolate + Potassium chloride Maggiore
- Amitriptyline + Glycopyrrolate Moderata
- Atropine + Glycopyrrolate Moderata
- Bethanechol + Glycopyrrolate Moderata
- Clomipramine + Glycopyrrolate Moderata
- Clozapine + Glycopyrrolate Moderata
Domande frequenti
Can I take Chlorpromazine with Glycopyrrolate?
MediHelp rates the interaction as moderate. Chlorpromazine and Glycopyrrolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine has anticholinergic properties that add to those of glycopyrrolate. This may cause dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion, and in severe cases reduced gut motility or ileus.
How serious is the interaction between Chlorpromazine and Glycopyrrolate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects, especially in older patients, and for constipation or urinary retention. Reduce the dose of one agent or choose an alternative if symptoms become troublesome.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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