Interazioni tra farmaci
Chlorpromazine + Panobinostat
Gravità: Controindicata
Chlorpromazine and Panobinostat: contraindicated interaction.
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Sintesi
Panobinostat prolongs the QT interval and chlorpromazine has the same effect, so using both increases the risk of torsade de pointes. Panobinostat labeling advises against use with QT-prolonging drugs.
Cosa significa questa interazione in parole semplici
Chlorpromazine and Panobinostat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Chlorpromazine belongs to Central Nervous System; Panobinostat belongs to Oncology.
Perché avviene
Additive QT prolongation through effects on cardiac repolarization.
Cosa fare
Do not use together; choose an antipsychotic or antiemetic without QT effect. If unavoidable, monitor ECG and electrolytes intensively.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Chlorpromazine
- Chlorpromazine + Dofetilide Controindicata
- Chlorpromazine + Dronedarone Controindicata
- Chlorpromazine + Droperidol Controindicata
- Chlorpromazine + Ibutilide Controindicata
- Chlorpromazine + Metrizamide Controindicata
- Chlorpromazine + Pimozide Controindicata
Altre interazioni di Panobinostat
- Amiodarone + Panobinostat Controindicata
- Anagrelide + Panobinostat Controindicata
- Chloroquine + Panobinostat Controindicata
- Dronedarone + Panobinostat Controindicata
- Haloperidol + Panobinostat Controindicata
- Moxifloxacin + Panobinostat Controindicata
Domande frequenti
Can I take Chlorpromazine with Panobinostat?
MediHelp rates the interaction as contraindicated. Chlorpromazine and Panobinostat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Panobinostat prolongs the QT interval and chlorpromazine has the same effect, so using both increases the risk of torsade de pointes. Panobinostat labeling advises against use with QT-prolonging drugs.
How serious is the interaction between Chlorpromazine and Panobinostat?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose an antipsychotic or antiemetic without QT effect. If unavoidable, monitor ECG and electrolytes intensively.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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