Interazioni tra farmaci
Chlorpropamide + Sulphasalazine
Gravità: Moderata
Chlorpropamide and Sulphasalazine: moderate interaction.
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Sintesi
Sulfasalazine contains a sulfonamide-type moiety, and sulfonamide antibacterials are known to potentiate sulfonylurea hypoglycemia. Reports with sulfasalazine are sparse, but an enhanced glucose-lowering effect of chlorpropamide is plausible, and chlorpropamide's long half-life makes prolonged hypoglycemia a concern.
Cosa significa questa interazione in parole semplici
Chlorpropamide and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Sulphasalazine belongs to Gastrointestinal Tract.
Perché avviene
Possible displacement from plasma protein binding and/or reduced sulfonylurea clearance; the mechanism is not well established for sulfasalazine.
Cosa fare
Monitor blood glucose more frequently when sulfasalazine is started or stopped in patients on chlorpropamide. Reduce the sulfonylurea dose if hypoglycemia occurs and counsel the patient on its symptoms.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Sulphasalazine
- Deferiprone + Sulphasalazine Maggiore
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- Sepiapterin + Sulphasalazine Maggiore
- Acalabrutinib + Sulphasalazine Moderata
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- Acetazolamide + Sulphasalazine Moderata
Altre interazioni di Chlorpropamide
Domande frequenti
Can I take Chlorpropamide with Sulphasalazine?
MediHelp rates the interaction as moderate. Chlorpropamide and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfasalazine contains a sulfonamide-type moiety, and sulfonamide antibacterials are known to potentiate sulfonylurea hypoglycemia. Reports with sulfasalazine are sparse, but an enhanced glucose-lowering effect of chlorpropamide is plausible, and chlorpropamide's long half-life makes prolonged hypoglycemia a concern.
How serious is the interaction between Chlorpropamide and Sulphasalazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when sulfasalazine is started or stopped in patients on chlorpropamide. Reduce the sulfonylurea dose if hypoglycemia occurs and counsel the patient on its symptoms.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
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