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Interazioni tra farmaci

Cisatracurium + Lincomycin

Gravità: Maggiore

Cisatracurium and Lincomycin: major interaction.

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Sintesi

Lincomycin has neuromuscular blocking activity and can potentiate non-depolarizing relaxants such as cisatracurium. This can prolong paralysis and delay return of spontaneous ventilation.

Cosa significa questa interazione in parole semplici

Cisatracurium and Lincomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Cisatracurium belongs to Musculoskeletal; Lincomycin belongs to Anti Bacterial.

Livello di evidenza: Moderate

Perché avviene

Additive neuromuscular blockade via presynaptic and postsynaptic inhibition of transmission by lincomycin.

Cosa fare

Monitor train-of-four and titrate cisatracurium cautiously. Keep ventilatory support available until full recovery of neuromuscular function.

Cosa chiedere al farmacista

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Cisatracurium with Lincomycin?

MediHelp rates the interaction as major. Cisatracurium and Lincomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lincomycin has neuromuscular blocking activity and can potentiate non-depolarizing relaxants such as cisatracurium. This can prolong paralysis and delay return of spontaneous ventilation.

How serious is the interaction between Cisatracurium and Lincomycin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor train-of-four and titrate cisatracurium cautiously. Keep ventilatory support available until full recovery of neuromuscular function.

What other medicines interact with Cisatracurium?

MediHelp also lists interactions of Cisatracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Cisatracurium page.

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