Drug interactions
Cisatracurium + Lincomycin
Severity: Major
Cisatracurium and Lincomycin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lincomycin has neuromuscular blocking activity and can potentiate non-depolarizing relaxants such as cisatracurium. This can prolong paralysis and delay return of spontaneous ventilation.
What this interaction means in plain words
Cisatracurium and Lincomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cisatracurium belongs to Musculoskeletal; Lincomycin belongs to Anti Bacterial.
Why it happens
Additive neuromuscular blockade via presynaptic and postsynaptic inhibition of transmission by lincomycin.
What to do
Monitor train-of-four and titrate cisatracurium cautiously. Keep ventilatory support available until full recovery of neuromuscular function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cisatracurium
Other interactions of Lincomycin
- Atracurium + Lincomycin Major
- Lincomycin + Pancuronium Major
- Lincomycin + Rapacuronium Major
- Lincomycin + Rocuronium Major
- Lincomycin + Vecuronium Major
- Cholera vaccine + Lincomycin Moderate
Frequently asked questions
Can I take Cisatracurium with Lincomycin?
MediHelp rates the interaction as major. Cisatracurium and Lincomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lincomycin has neuromuscular blocking activity and can potentiate non-depolarizing relaxants such as cisatracurium. This can prolong paralysis and delay return of spontaneous ventilation.
How serious is the interaction between Cisatracurium and Lincomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor train-of-four and titrate cisatracurium cautiously. Keep ventilatory support available until full recovery of neuromuscular function.
What other medicines interact with Cisatracurium?
MediHelp also lists interactions of Cisatracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Cisatracurium page.
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