Interazioni tra farmaci
Clarithromycin + Duvelisib
Gravità: Maggiore
Clarithromycin and Duvelisib: major interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Clarithromycin significantly raises duvelisib exposure, increasing the risk of serious infections, diarrhea or colitis, cutaneous reactions and pneumonitis. Duvelisib may also inhibit CYP3A4 and raise clarithromycin levels.
Cosa significa questa interazione in parole semplici
Clarithromycin and Duvelisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Duvelisib belongs to Oncology.
Perché avviene
Clarithromycin is a strong CYP3A4 inhibitor that reduces duvelisib metabolism; duvelisib is itself a CYP3A4 inhibitor.
Cosa fare
Reduce duvelisib to 15 mg twice daily during the combination, as labeled. Monitor for toxicity, or use a non-CYP3A4-inhibiting antibiotic.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Clarithromycin e Duvelisib, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Altre interazioni di Clarithromycin
- Astemizole + Clarithromycin Controindicata
- Avanafil + Clarithromycin Controindicata
- Cisapride + Clarithromycin Controindicata
- Clarithromycin + Colchicine Controindicata
- Clarithromycin + Conivaptan Controindicata
- Clarithromycin + Dihydroergotamine Controindicata
Altre interazioni di Duvelisib
- Duvelisib + Ergotamine Controindicata
- Alfuzosin + Duvelisib Maggiore
- Apalutamide + Duvelisib Maggiore
- Avanafil + Duvelisib Maggiore
- Carbamazepine + Duvelisib Maggiore
- Chloramphenicol + Duvelisib Maggiore
Domande frequenti
Can I take Clarithromycin with Duvelisib?
MediHelp rates the interaction as major. Clarithromycin and Duvelisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin significantly raises duvelisib exposure, increasing the risk of serious infections, diarrhea or colitis, cutaneous reactions and pneumonitis. Duvelisib may also inhibit CYP3A4 and raise clarithromycin levels.
How serious is the interaction between Clarithromycin and Duvelisib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce duvelisib to 15 mg twice daily during the combination, as labeled. Monitor for toxicity, or use a non-CYP3A4-inhibiting antibiotic.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
