Interazioni tra farmaci
Duvelisib + Ergotamine
Gravità: Controindicata
Duvelisib and Ergotamine: contraindicated interaction.
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Sintesi
Duvelisib inhibits CYP3A4 and can raise exposure to sensitive CYP3A4 substrates. Ergotamine is cleared mainly by CYP3A4, and higher levels carry a risk of ergotism with severe peripheral and cerebral vasospasm and ischemia.
Cosa significa questa interazione in parole semplici
Duvelisib and Ergotamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Duvelisib belongs to Oncology; Ergotamine belongs to Central Nervous System.
Perché avviene
Duvelisib inhibits CYP3A4, reducing the first-pass and systemic metabolism of ergotamine.
Cosa fare
Avoid combining ergotamine with duvelisib and choose a non-ergot acute migraine treatment. If it cannot be avoided, monitor closely for ischemic symptoms such as cold or numb extremities and chest pain.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Ergotamine
- Almotriptan + Ergotamine Controindicata
- Atazanavir + Ergotamine Controindicata
- Clarithromycin + Ergotamine Controindicata
- Cobicistat + Ergotamine Controindicata
- Darunavir + Ergotamine Controindicata
- Dihydroergotamine intranasal + Ergotamine Controindicata
Altre interazioni di Duvelisib
- Alfuzosin + Duvelisib Maggiore
- Apalutamide + Duvelisib Maggiore
- Avanafil + Duvelisib Maggiore
- Carbamazepine + Duvelisib Maggiore
- Chloramphenicol + Duvelisib Maggiore
- Clarithromycin + Duvelisib Maggiore
Domande frequenti
Can I take Duvelisib with Ergotamine?
MediHelp rates the interaction as contraindicated. Duvelisib and Ergotamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Duvelisib inhibits CYP3A4 and can raise exposure to sensitive CYP3A4 substrates. Ergotamine is cleared mainly by CYP3A4, and higher levels carry a risk of ergotism with severe peripheral and cerebral vasospasm and ischemia.
How serious is the interaction between Duvelisib and Ergotamine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining ergotamine with duvelisib and choose a non-ergot acute migraine treatment. If it cannot be avoided, monitor closely for ischemic symptoms such as cold or numb extremities and chest pain.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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