Interazioni tra farmaci
Clarithromycin + Elacestrant
Gravità: Maggiore
Clarithromycin and Elacestrant: major interaction.
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Sintesi
Strong CYP3A4 inhibitors increase elacestrant exposure and may worsen its adverse effects such as nausea, dyslipidemia and musculoskeletal pain. Labeling advises avoiding concomitant use with strong or moderate CYP3A4 inhibitors.
Cosa significa questa interazione in parole semplici
Clarithromycin and Elacestrant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Elacestrant belongs to Oncology.
Perché avviene
Clarithromycin inhibits CYP3A4, the main metabolic pathway of elacestrant.
Cosa fare
Avoid the combination and use an antibiotic that does not inhibit CYP3A4, such as azithromycin. If clarithromycin is unavoidable, monitor for elacestrant toxicity.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Clarithromycin
- Astemizole + Clarithromycin Controindicata
- Avanafil + Clarithromycin Controindicata
- Cisapride + Clarithromycin Controindicata
- Clarithromycin + Colchicine Controindicata
- Clarithromycin + Conivaptan Controindicata
- Clarithromycin + Dihydroergotamine Controindicata
Altre interazioni di Elacestrant
- Amobarbital + Elacestrant Maggiore
- Apalutamide + Elacestrant Maggiore
- Aprepitant + Elacestrant Maggiore
- Armodafinil + Elacestrant Maggiore
- Carbamazepine + Elacestrant Maggiore
- Efavirenz + Elacestrant Maggiore
Domande frequenti
Can I take Clarithromycin with Elacestrant?
MediHelp rates the interaction as major. Clarithromycin and Elacestrant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Strong CYP3A4 inhibitors increase elacestrant exposure and may worsen its adverse effects such as nausea, dyslipidemia and musculoskeletal pain. Labeling advises avoiding concomitant use with strong or moderate CYP3A4 inhibitors.
How serious is the interaction between Clarithromycin and Elacestrant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an antibiotic that does not inhibit CYP3A4, such as azithromycin. If clarithromycin is unavoidable, monitor for elacestrant toxicity.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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