Interazioni tra farmaci
Clarithromycin + Glyburide
Gravità: Maggiore
Clarithromycin and Glyburide: major interaction.
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Sintesi
Clarithromycin has been linked to severe hypoglycemia in patients taking glyburide, especially older adults and those with renal dysfunction. Clarithromycin may also increase glyburide exposure by inhibiting transport and metabolism.
Cosa significa questa interazione in parole semplici
Clarithromycin and Glyburide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Glyburide belongs to Endocrine.
Perché avviene
Clarithromycin may inhibit CYP3A4 and OATP/P-glycoprotein handling of glyburide, while also enhancing insulin secretion.
Cosa fare
Avoid the combination if possible or use azithromycin instead. If used together, monitor blood glucose frequently and reduce the glyburide dose.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Clarithromycin
- Astemizole + Clarithromycin Controindicata
- Avanafil + Clarithromycin Controindicata
- Cisapride + Clarithromycin Controindicata
- Clarithromycin + Colchicine Controindicata
- Clarithromycin + Conivaptan Controindicata
- Clarithromycin + Dihydroergotamine Controindicata
Altre interazioni di Glyburide
- Bosentan + Glyburide Controindicata
- Cholic acid + Glyburide Maggiore
- Ciprofloxacin + Glyburide Maggiore
- Fluconazole + Glyburide Maggiore
- Glyburide + Insulin degludec-liraglutide Maggiore
- Glyburide + Miconazole Maggiore
Domande frequenti
Can I take Clarithromycin with Glyburide?
MediHelp rates the interaction as major. Clarithromycin and Glyburide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin has been linked to severe hypoglycemia in patients taking glyburide, especially older adults and those with renal dysfunction. Clarithromycin may also increase glyburide exposure by inhibiting transport and metabolism.
How serious is the interaction between Clarithromycin and Glyburide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible or use azithromycin instead. If used together, monitor blood glucose frequently and reduce the glyburide dose.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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