Interazioni tra farmaci
Clarithromycin + Ranolazine
Gravità: Controindicata
Clarithromycin and Ranolazine: contraindicated interaction.
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Sintesi
Clarithromycin markedly raises ranolazine concentrations, increasing dose-related QT prolongation, dizziness and nausea. Ranolazine is contraindicated with strong CYP3A inhibitors.
Cosa significa questa interazione in parole semplici
Clarithromycin and Ranolazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clarithromycin belongs to Anti Bacterial; Ranolazine belongs to Cardiovascular.
Perché avviene
Strong CYP3A4 and P-gp inhibition reduces ranolazine metabolism and clearance.
Cosa fare
Do not combine; use azithromycin or another antibiotic, or withhold ranolazine during a short clarithromycin course.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Clarithromycin
- Astemizole + Clarithromycin Controindicata
- Avanafil + Clarithromycin Controindicata
- Cisapride + Clarithromycin Controindicata
- Clarithromycin + Colchicine Controindicata
- Clarithromycin + Conivaptan Controindicata
- Clarithromycin + Dihydroergotamine Controindicata
Altre interazioni di Ranolazine
- Adagrasib + Ranolazine Controindicata
- Amobarbital + Ranolazine Controindicata
- Apalutamide + Ranolazine Controindicata
- Butabarbital + Ranolazine Controindicata
- Carbamazepine + Ranolazine Controindicata
- Cobicistat + Ranolazine Controindicata
Domande frequenti
Can I take Clarithromycin with Ranolazine?
MediHelp rates the interaction as contraindicated. Clarithromycin and Ranolazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clarithromycin markedly raises ranolazine concentrations, increasing dose-related QT prolongation, dizziness and nausea. Ranolazine is contraindicated with strong CYP3A inhibitors.
How serious is the interaction between Clarithromycin and Ranolazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use azithromycin or another antibiotic, or withhold ranolazine during a short clarithromycin course.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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