Drug interactions
Clarithromycin + Ranolazine
Severity: Contraindicated
Clarithromycin and Ranolazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin markedly raises ranolazine concentrations, increasing dose-related QT prolongation, dizziness and nausea. Ranolazine is contraindicated with strong CYP3A inhibitors.
What this interaction means in plain words
Clarithromycin and Ranolazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clarithromycin belongs to Anti Bacterial; Ranolazine belongs to Cardiovascular.
Why it happens
Strong CYP3A4 and P-gp inhibition reduces ranolazine metabolism and clearance.
What to do
Do not combine; use azithromycin or another antibiotic, or withhold ranolazine during a short clarithromycin course.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Cobicistat + Ranolazine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Ranolazine?
MediHelp rates the interaction as contraindicated. Clarithromycin and Ranolazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clarithromycin markedly raises ranolazine concentrations, increasing dose-related QT prolongation, dizziness and nausea. Ranolazine is contraindicated with strong CYP3A inhibitors.
How serious is the interaction between Clarithromycin and Ranolazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use azithromycin or another antibiotic, or withhold ranolazine during a short clarithromycin course.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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