Interazioni tra farmaci
Clotrimazole + Eliglustat
Gravità: Moderata
Clotrimazole and Eliglustat: moderate interaction.
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Sintesi
Clotrimazole may increase eliglustat exposure through CYP3A4 inhibition, which can prolong the PR, QRS and QT intervals at high concentrations. The risk is greatest in poor or intermediate CYP2D6 metabolizers.
Cosa significa questa interazione in parole semplici
Clotrimazole and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clotrimazole belongs to Anti Fungals; Eliglustat belongs to Miscellaneous.
Perché avviene
Clotrimazole inhibits CYP3A4, which contributes to eliglustat metabolism, particularly when CYP2D6 is limited.
Cosa fare
Prefer topical clotrimazole with minimal absorption or an alternative antifungal. If systemic use is needed, check CYP2D6 status and monitor ECG, adjusting eliglustat per labeling.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Clotrimazole
- Clotrimazole + Lomitapide Maggiore
- Clotrimazole + Mavacamten Maggiore
- Clotrimazole + Mobocertinib Maggiore
- Clotrimazole + Voclosporin Maggiore
- Bosutinib + Clotrimazole Moderata
- Cannabidiol + Clotrimazole Moderata
Altre interazioni di Eliglustat
- Amiodarone + Eliglustat Controindicata
- Clarithromycin + Eliglustat Controindicata
- Dronedarone + Eliglustat Controindicata
- Eliglustat + Itraconazole Controindicata
- Eliglustat + Ketoconazole Controindicata
- Eliglustat + Pimozide Controindicata
Domande frequenti
Can I take Clotrimazole with Eliglustat?
MediHelp rates the interaction as moderate. Clotrimazole and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clotrimazole may increase eliglustat exposure through CYP3A4 inhibition, which can prolong the PR, QRS and QT intervals at high concentrations. The risk is greatest in poor or intermediate CYP2D6 metabolizers.
How serious is the interaction between Clotrimazole and Eliglustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer topical clotrimazole with minimal absorption or an alternative antifungal. If systemic use is needed, check CYP2D6 status and monitor ECG, adjusting eliglustat per labeling.
What other medicines interact with Clotrimazole?
MediHelp also lists interactions of Clotrimazole with, for example, Lomitapide, Mavacamten, Mobocertinib. The full list is on the Clotrimazole page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
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