Interazioni tra farmaci
Eliglustat + Itraconazole
Gravità: Controindicata
Eliglustat and Itraconazole: contraindicated interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Itraconazole strongly increases eliglustat exposure, and both can prolong the QT interval. This raises the risk of cardiac conduction abnormalities and arrhythmia.
Cosa significa questa interazione in parole semplici
Eliglustat and Itraconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Eliglustat belongs to Miscellaneous; Itraconazole belongs to Anti Fungals.
Perché avviene
Strong CYP3A4 inhibition raises eliglustat levels, with additive QT prolongation.
Cosa fare
Avoid the combination, and especially so in CYP2D6 poor or intermediate metabolizers. Consider an alternative antifungal.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Eliglustat e Itraconazole, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Altre interazioni di Itraconazole
- Alfuzosin + Itraconazole Controindicata
- Alprazolam + Itraconazole Controindicata
- Avanafil + Itraconazole Controindicata
- Conivaptan + Itraconazole Controindicata
- Dihydroergotamine intranasal + Itraconazole Controindicata
- Dihydroergotamine + Itraconazole Controindicata
Altre interazioni di Eliglustat
- Amiodarone + Eliglustat Controindicata
- Clarithromycin + Eliglustat Controindicata
- Dronedarone + Eliglustat Controindicata
- Eliglustat + Ketoconazole Controindicata
- Eliglustat + Pimozide Controindicata
- Eliglustat + Posaconazole Controindicata
Domande frequenti
Can I take Eliglustat with Itraconazole?
MediHelp rates the interaction as contraindicated. Eliglustat and Itraconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Itraconazole strongly increases eliglustat exposure, and both can prolong the QT interval. This raises the risk of cardiac conduction abnormalities and arrhythmia.
How serious is the interaction between Eliglustat and Itraconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, and especially so in CYP2D6 poor or intermediate metabolizers. Consider an alternative antifungal.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
