Interazioni tra farmaci
Cocaine + Desipramine
Gravità: Maggiore
Cocaine and Desipramine: major interaction.
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Sintesi
Tricyclics block catecholamine reuptake, and cocaine does the same, so the sympathomimetic effects may be potentiated. With topical cocaine this is mainly relevant when large doses are absorbed, with risk of hypertension and arrhythmia.
Cosa significa questa interazione in parole semplici
Cocaine and Desipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cocaine belongs to Central Nervous System; Desipramine belongs to Central Nervous System.
Perché avviene
Additive inhibition of norepinephrine reuptake, increasing adrenergic stimulation and arrhythmia risk.
Cosa fare
Avoid cocaine in patients taking desipramine, including topical anesthetic use, where an alternative anesthetic can be chosen. If unavoidable, use the minimum dose and monitor blood pressure and ECG.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Desipramine
- Desipramine + Disopyramide Controindicata
- Desipramine + Dofetilide Controindicata
- Desipramine + Ibutilide Controindicata
- Desipramine + Isocarboxazid Controindicata
- Desipramine + Methylene blue Controindicata
- Desipramine + Pentamidine Controindicata
Altre interazioni di Cocaine
- Cocaine + Isocarboxazid Controindicata
- Cocaine + Phenelzine Controindicata
- Cocaine + Procarbazine Controindicata
- Amitriptyline + Cocaine Maggiore
- Bisoprolol + Cocaine Maggiore
- Citalopram + Cocaine Maggiore
Domande frequenti
Can I take Cocaine with Desipramine?
MediHelp rates the interaction as major. Cocaine and Desipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tricyclics block catecholamine reuptake, and cocaine does the same, so the sympathomimetic effects may be potentiated. With topical cocaine this is mainly relevant when large doses are absorbed, with risk of hypertension and arrhythmia.
How serious is the interaction between Cocaine and Desipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid cocaine in patients taking desipramine, including topical anesthetic use, where an alternative anesthetic can be chosen. If unavoidable, use the minimum dose and monitor blood pressure and ECG.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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