Interazioni tra farmaci
Cocaine + Procarbazine
Gravità: Controindicata
Cocaine and Procarbazine: contraindicated interaction.
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Sintesi
Cocaine blocks catecholamine and serotonin reuptake, and with an MAO inhibitor such as procarbazine there is risk of hypertensive crisis, arrhythmia and serotonin toxicity. Topical medical cocaine has limited absorption but the combination is still advised against.
Cosa significa questa interazione in parole semplici
Cocaine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cocaine belongs to Central Nervous System; Procarbazine belongs to Oncology.
Perché avviene
MAO inhibition increases monoamine stores while cocaine blocks reuptake, producing additive sympathomimetic and serotonergic effects.
Cosa fare
Avoid cocaine, including topical use, during and for 2 weeks after procarbazine. Use an alternative local anesthetic.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Controindicata
- Amitriptyline + Procarbazine Controindicata
- Amoxapine + Procarbazine Controindicata
- Atomoxetine + Procarbazine Controindicata
- Bcg vaccine live + Procarbazine Controindicata
- Brimonidine + Procarbazine Controindicata
Altre interazioni di Cocaine
- Cocaine + Isocarboxazid Controindicata
- Cocaine + Phenelzine Controindicata
- Amitriptyline + Cocaine Maggiore
- Bisoprolol + Cocaine Maggiore
- Citalopram + Cocaine Maggiore
- Clomipramine + Cocaine Maggiore
Domande frequenti
Can I take Cocaine with Procarbazine?
MediHelp rates the interaction as contraindicated. Cocaine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cocaine blocks catecholamine and serotonin reuptake, and with an MAO inhibitor such as procarbazine there is risk of hypertensive crisis, arrhythmia and serotonin toxicity. Topical medical cocaine has limited absorption but the combination is still advised against.
How serious is the interaction between Cocaine and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid cocaine, including topical use, during and for 2 weeks after procarbazine. Use an alternative local anesthetic.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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