Interazioni tra farmaci
Cocaine + Isocarboxazid
Gravità: Controindicata
Cocaine and Isocarboxazid: contraindicated interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Cocaine blocks reuptake of catecholamines and serotonin, and with an MAOI it may cause severe hypertension, arrhythmias or serotonin toxicity. Topical medical use gives lower exposure but still carries risk.
Cosa significa questa interazione in parole semplici
Cocaine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cocaine belongs to Central Nervous System; Isocarboxazid belongs to Central Nervous System.
Perché avviene
Monoamine reuptake inhibition combined with inhibited monoamine metabolism increases synaptic catecholamines and serotonin.
Cosa fare
Avoid cocaine in patients on MAOIs, including topical anesthetic use; choose a different local anesthetic.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Cocaine e Isocarboxazid, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Altre interazioni di Isocarboxazid
- 5-HTP + Isocarboxazid Controindicata
- Amitriptyline + Isocarboxazid Controindicata
- Amobarbital + Isocarboxazid Controindicata
- Amoxapine + Isocarboxazid Controindicata
- Apraclonidine + Isocarboxazid Controindicata
- Atomoxetine + Isocarboxazid Controindicata
Altre interazioni di Cocaine
- Cocaine + Phenelzine Controindicata
- Cocaine + Procarbazine Controindicata
- Amitriptyline + Cocaine Maggiore
- Bisoprolol + Cocaine Maggiore
- Citalopram + Cocaine Maggiore
- Clomipramine + Cocaine Maggiore
Domande frequenti
Can I take Cocaine with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Cocaine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cocaine blocks reuptake of catecholamines and serotonin, and with an MAOI it may cause severe hypertension, arrhythmias or serotonin toxicity. Topical medical use gives lower exposure but still carries risk.
How serious is the interaction between Cocaine and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid cocaine in patients on MAOIs, including topical anesthetic use; choose a different local anesthetic.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
