Interazioni tra farmaci
Colchicine + Cyclosporine
Gravità: Controindicata
Colchicine and Cyclosporine: contraindicated interaction.
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Sintesi
Cyclosporine inhibits P-glycoprotein and CYP3A4, both of which clear colchicine, so colchicine exposure rises substantially. Fatal colchicine toxicity and myopathy have been reported with this pairing, and cyclosporine itself can cause myotoxicity and nephrotoxicity.
Cosa significa questa interazione in parole semplici
Colchicine and Cyclosporine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Cyclosporine inhibits P-gp efflux and CYP3A4 metabolism of colchicine, increasing its exposure.
Cosa fare
Avoid the combination, and it is contraindicated in patients with renal or hepatic impairment. If colchicine is essential, use a substantially reduced dose per labeling and monitor closely for myopathy, cytopenias and diarrhea.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Colchicine
- Clarithromycin + Colchicine Controindicata
- Cobicistat + Colchicine Controindicata
- Colchicine + Ensitrelvir Controindicata
- Colchicine + Levoketoconazole Controindicata
- Colchicine + Nirmatrelvir Controindicata
- Colchicine + Nirmatrelvir / ritonavir Controindicata
Domande frequenti
Can I take Colchicine with Cyclosporine?
MediHelp rates the interaction as contraindicated. Colchicine and Cyclosporine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cyclosporine inhibits P-glycoprotein and CYP3A4, both of which clear colchicine, so colchicine exposure rises substantially. Fatal colchicine toxicity and myopathy have been reported with this pairing, and cyclosporine itself can cause myotoxicity and nephrotoxicity.
How serious is the interaction between Colchicine and Cyclosporine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, and it is contraindicated in patients with renal or hepatic impairment. If colchicine is essential, use a substantially reduced dose per labeling and monitor closely for myopathy, cytopenias and diarrhea.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Ensitrelvir. The full list is on the Colchicine page.
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