Interazioni tra farmaci
Colchicine + Nirmatrelvir / ritonavir
Gravità: Controindicata
Colchicine and Nirmatrelvir / ritonavir: contraindicated interaction.
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Sintesi
Ritonavir strongly inhibits CYP3A4 and P-glycoprotein and can greatly raise colchicine levels. This may cause fatal colchicine toxicity including bone marrow suppression, multiorgan failure and neuromuscular toxicity, especially in renal or hepatic impairment.
Cosa significa questa interazione in parole semplici
Colchicine and Nirmatrelvir / ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Inhibition of CYP3A4 and P-glycoprotein by ritonavir reduces colchicine clearance.
Cosa fare
Avoid the combination; hold colchicine during the antiviral course or choose an alternative. Do not combine in patients with renal or hepatic impairment.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Colchicine
- Clarithromycin + Colchicine Controindicata
- Cobicistat + Colchicine Controindicata
- Colchicine + Cyclosporine Controindicata
- Colchicine + Ensitrelvir Controindicata
- Colchicine + Levoketoconazole Controindicata
- Colchicine + Nirmatrelvir Controindicata
Domande frequenti
Can I take Colchicine with Nirmatrelvir / ritonavir?
MediHelp rates the interaction as contraindicated. Colchicine and Nirmatrelvir / ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ritonavir strongly inhibits CYP3A4 and P-glycoprotein and can greatly raise colchicine levels. This may cause fatal colchicine toxicity including bone marrow suppression, multiorgan failure and neuromuscular toxicity, especially in renal or hepatic impairment.
How serious is the interaction between Colchicine and Nirmatrelvir / ritonavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; hold colchicine during the antiviral course or choose an alternative. Do not combine in patients with renal or hepatic impairment.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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