Interazioni tra farmaci
Colchicine + Levoketoconazole
Gravità: Controindicata
Colchicine and Levoketoconazole: contraindicated interaction.
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Sintesi
Levoketoconazole is a strong CYP3A4 and P-gp inhibitor and can markedly raise colchicine levels. This risks severe colchicine toxicity, with the greatest danger in renal or hepatic impairment.
Cosa significa questa interazione in parole semplici
Colchicine and Levoketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Colchicine belongs to Genitourinary; Levoketoconazole belongs to Endocrine.
Perché avviene
Levoketoconazole inhibits CYP3A4 metabolism and P-gp efflux of colchicine.
Cosa fare
Avoid the combination, especially in renal or hepatic impairment. Use a different agent for the colchicine indication where possible.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Colchicine
- Clarithromycin + Colchicine Controindicata
- Cobicistat + Colchicine Controindicata
- Colchicine + Cyclosporine Controindicata
- Colchicine + Ensitrelvir Controindicata
- Colchicine + Nirmatrelvir Controindicata
- Colchicine + Nirmatrelvir / ritonavir Controindicata
Altre interazioni di Levoketoconazole
- Alfuzosin + Levoketoconazole Controindicata
- Alprazolam + Levoketoconazole Controindicata
- Amiodarone + Levoketoconazole Controindicata
- Avanafil + Levoketoconazole Controindicata
- Cisapride + Levoketoconazole Controindicata
- Clarithromycin + Levoketoconazole Controindicata
Domande frequenti
Can I take Colchicine with Levoketoconazole?
MediHelp rates the interaction as contraindicated. Colchicine and Levoketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levoketoconazole is a strong CYP3A4 and P-gp inhibitor and can markedly raise colchicine levels. This risks severe colchicine toxicity, with the greatest danger in renal or hepatic impairment.
How serious is the interaction between Colchicine and Levoketoconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, especially in renal or hepatic impairment. Use a different agent for the colchicine indication where possible.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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