Interazioni tra farmaci
Colchicine + Erdafitinib
Gravità: Maggiore
Colchicine and Erdafitinib: major interaction.
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Sintesi
Erdafitinib inhibits P-glycoprotein and may increase colchicine exposure. Colchicine has a narrow therapeutic index, so higher levels may cause serious toxicity.
Cosa significa questa interazione in parole semplici
Colchicine and Erdafitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Colchicine belongs to Genitourinary; Erdafitinib belongs to Oncology.
Perché avviene
P-gp inhibition by erdafitinib reduces colchicine efflux and clearance.
Cosa fare
If unavoidable, separate colchicine from erdafitinib by at least 6 hours, consider reducing the colchicine dose, and monitor for toxicity.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Colchicine
- Clarithromycin + Colchicine Controindicata
- Cobicistat + Colchicine Controindicata
- Colchicine + Cyclosporine Controindicata
- Colchicine + Ensitrelvir Controindicata
- Colchicine + Levoketoconazole Controindicata
- Colchicine + Nirmatrelvir Controindicata
Altre interazioni di Erdafitinib
- Amobarbital + Erdafitinib Maggiore
- Apalutamide + Erdafitinib Maggiore
- Carbamazepine + Erdafitinib Maggiore
- Chloramphenicol + Erdafitinib Maggiore
- Clarithromycin + Erdafitinib Maggiore
- Dabigatran etexilate + Erdafitinib Maggiore
Domande frequenti
Can I take Colchicine with Erdafitinib?
MediHelp rates the interaction as major. Colchicine and Erdafitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erdafitinib inhibits P-glycoprotein and may increase colchicine exposure. Colchicine has a narrow therapeutic index, so higher levels may cause serious toxicity.
How serious is the interaction between Colchicine and Erdafitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If unavoidable, separate colchicine from erdafitinib by at least 6 hours, consider reducing the colchicine dose, and monitor for toxicity.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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