Interazioni tra farmaci
Conivaptan + Erythromycin
Gravità: Controindicata
Conivaptan and Erythromycin: contraindicated interaction.
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Sintesi
Erythromycin is a CYP3A4 inhibitor and conivaptan is a CYP3A4 substrate and inhibitor, so concentrations of conivaptan may rise, causing excessive vasopressin antagonism with overly rapid sodium correction. Conivaptan labeling contraindicates potent CYP3A4 inhibitors.
Cosa significa questa interazione in parole semplici
Conivaptan and Erythromycin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Erythromycin inhibits CYP3A4 metabolism of conivaptan.
Cosa fare
Avoid the combination and use a non-CYP3A4-inhibiting antibiotic. If exposure occurs, monitor serum sodium frequently to prevent overly rapid correction.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Erythromycin
- Dihydroergotamine intranasal + Erythromycin Controindicata
- Dihydroergotamine + Erythromycin Controindicata
- Domperidone + Erythromycin Controindicata
- Dronedarone + Erythromycin Controindicata
- Droperidol + Erythromycin Controindicata
- Ergotamine + Erythromycin Controindicata
Domande frequenti
Can I take Conivaptan with Erythromycin?
MediHelp rates the interaction as contraindicated. Conivaptan and Erythromycin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Erythromycin is a CYP3A4 inhibitor and conivaptan is a CYP3A4 substrate and inhibitor, so concentrations of conivaptan may rise, causing excessive vasopressin antagonism with overly rapid sodium correction. Conivaptan labeling contraindicates potent CYP3A4 inhibitors.
How serious is the interaction between Conivaptan and Erythromycin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-CYP3A4-inhibiting antibiotic. If exposure occurs, monitor serum sodium frequently to prevent overly rapid correction.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Domperidone. The full list is on the Erythromycin page.
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