Interazioni tra farmaci
Dihydroergotamine intranasal + Erythromycin
Gravità: Controindicata
Dihydroergotamine intranasal and Erythromycin: contraindicated interaction.
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Sintesi
Erythromycin raises systemic dihydroergotamine levels even with the intranasal form, risking ergotism with vasospasm and tissue ischemia. Labeling contraindicates use with potent CYP3A4 inhibitors.
Cosa significa questa interazione in parole semplici
Dihydroergotamine intranasal and Erythromycin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Erythromycin inhibits CYP3A4 metabolism of dihydroergotamine.
Cosa fare
Avoid the combination; select a non-CYP3A4-inhibiting antibiotic and alternative migraine therapy during the antibiotic course.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Erythromycin
- Conivaptan + Erythromycin Controindicata
- Dihydroergotamine + Erythromycin Controindicata
- Domperidone + Erythromycin Controindicata
- Dronedarone + Erythromycin Controindicata
- Droperidol + Erythromycin Controindicata
- Ergotamine + Erythromycin Controindicata
Domande frequenti
Can I take Dihydroergotamine intranasal with Erythromycin?
MediHelp rates the interaction as contraindicated. Dihydroergotamine intranasal and Erythromycin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Erythromycin raises systemic dihydroergotamine levels even with the intranasal form, risking ergotism with vasospasm and tissue ischemia. Labeling contraindicates use with potent CYP3A4 inhibitors.
How serious is the interaction between Dihydroergotamine intranasal and Erythromycin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; select a non-CYP3A4-inhibiting antibiotic and alternative migraine therapy during the antibiotic course.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine, Domperidone. The full list is on the Erythromycin page.
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