Interazioni tra farmaci
Dihydroergotamine + Erythromycin
Gravità: Controindicata
Dihydroergotamine and Erythromycin: contraindicated interaction.
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Sintesi
Erythromycin markedly raises dihydroergotamine exposure, which can cause ergotism with severe peripheral and cerebral vasospasm and ischemia. This is a labeled contraindication with potent CYP3A4 inhibitors.
Cosa significa questa interazione in parole semplici
Dihydroergotamine and Erythromycin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dihydroergotamine belongs to Central Nervous System; Erythromycin belongs to Anti Bacterial.
Perché avviene
Erythromycin inhibits CYP3A4-mediated metabolism of dihydroergotamine.
Cosa fare
Do not coadminister; use a non-interacting antibiotic such as azithromycin or a different class. Watch for numbness, cold extremities and ischemia if exposure occurs.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Erythromycin
- Conivaptan + Erythromycin Controindicata
- Dihydroergotamine intranasal + Erythromycin Controindicata
- Domperidone + Erythromycin Controindicata
- Dronedarone + Erythromycin Controindicata
- Droperidol + Erythromycin Controindicata
- Ergotamine + Erythromycin Controindicata
Altre interazioni di Dihydroergotamine
- Almotriptan + Dihydroergotamine Controindicata
- Clarithromycin + Dihydroergotamine Controindicata
- Dihydroergotamine + Dopamine Controindicata
- Dihydroergotamine + Dronedarone Controindicata
- Dihydroergotamine + Efavirenz Controindicata
- Dihydroergotamine + Eletriptan Controindicata
Domande frequenti
Can I take Dihydroergotamine with Erythromycin?
MediHelp rates the interaction as contraindicated. Dihydroergotamine and Erythromycin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Erythromycin markedly raises dihydroergotamine exposure, which can cause ergotism with severe peripheral and cerebral vasospasm and ischemia. This is a labeled contraindication with potent CYP3A4 inhibitors.
How serious is the interaction between Dihydroergotamine and Erythromycin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use a non-interacting antibiotic such as azithromycin or a different class. Watch for numbness, cold extremities and ischemia if exposure occurs.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Domperidone. The full list is on the Erythromycin page.
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