Interazioni tra farmaci
Darunavir + Fluticasone-salmeterol
Gravità: Controindicata
Darunavir and Fluticasone-salmeterol: contraindicated interaction.
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Sintesi
Darunavir, usually given with ritonavir or cobicistat, strongly inhibits CYP3A4 and markedly raises salmeterol exposure. This can cause QT prolongation, palpitations and arrhythmias. It also raises systemic fluticasone levels, with a risk of Cushing's syndrome and adrenal suppression.
Cosa significa questa interazione in parole semplici
Darunavir and Fluticasone-salmeterol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Darunavir belongs to Anti Virals; Fluticasone-salmeterol belongs to Respiratory.
Perché avviene
Strong CYP3A4 inhibition by the boosted protease inhibitor reduces salmeterol and fluticasone clearance.
Cosa fare
Avoid the combination and use a non-CYP3A4-dependent alternative such as a different LABA or ICS (e.g., beclomethasone). If unavoidable, monitor ECG, potassium and adrenal function.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Fluticasone-salmeterol
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Controindicata
- Fluticasone-salmeterol + Fosamprenavir Controindicata
- Fluticasone-salmeterol + Indinavir Controindicata
- Fluticasone-salmeterol + Lopinavir Controindicata
- Fluticasone-salmeterol + Nelfinavir Controindicata
- Fluticasone-salmeterol + Ritonavir Controindicata
Altre interazioni di Darunavir
- Alfuzosin + Darunavir Controindicata
- Avanafil + Darunavir Controindicata
- Darunavir + Dronedarone Controindicata
- Darunavir + Eletriptan Controindicata
- Darunavir + Ergotamine Controindicata
- Darunavir + Flibanserin Controindicata
Domande frequenti
Can I take Darunavir with Fluticasone-salmeterol?
MediHelp rates the interaction as contraindicated. Darunavir and Fluticasone-salmeterol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Darunavir, usually given with ritonavir or cobicistat, strongly inhibits CYP3A4 and markedly raises salmeterol exposure. This can cause QT prolongation, palpitations and arrhythmias. It also raises systemic fluticasone levels, with a risk of Cushing's syndrome and adrenal suppression.
How serious is the interaction between Darunavir and Fluticasone-salmeterol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-CYP3A4-dependent alternative such as a different LABA or ICS (e.g., beclomethasone). If unavoidable, monitor ECG, potassium and adrenal function.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir, Indinavir. The full list is on the Fluticasone-salmeterol page.
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