Interazioni tra farmaci
Desvenlafaxine + Methylene blue
Gravità: Controindicata
Desvenlafaxine and Methylene blue: contraindicated interaction.
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Sintesi
Methylene blue inhibits MAO-A and can precipitate serotonin syndrome when given with desvenlafaxine. The reaction can be severe, with hyperthermia, neuromuscular hyperactivity, and altered mental status.
Cosa significa questa interazione in parole semplici
Desvenlafaxine and Methylene blue are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
MAO-A inhibition by methylene blue adds to serotonin and norepinephrine reuptake inhibition, causing excess serotonergic activity.
Cosa fare
Avoid the combination. If methylene blue is urgent, stop desvenlafaxine and monitor for serotonin syndrome for up to 2 weeks or until 24 hours after the last methylene blue dose, whichever comes first.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Controindicata
- Desvenlafaxine + Phenelzine Controindicata
- Desvenlafaxine + Rasagiline Controindicata
- Desvenlafaxine + Safinamide Controindicata
- Desvenlafaxine + Selegiline Controindicata
- Desvenlafaxine + Selegiline transdermal Controindicata
Domande frequenti
Can I take Desvenlafaxine with Methylene blue?
MediHelp rates the interaction as contraindicated. Desvenlafaxine and Methylene blue are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Methylene blue inhibits MAO-A and can precipitate serotonin syndrome when given with desvenlafaxine. The reaction can be severe, with hyperthermia, neuromuscular hyperactivity, and altered mental status.
How serious is the interaction between Desvenlafaxine and Methylene blue?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If methylene blue is urgent, stop desvenlafaxine and monitor for serotonin syndrome for up to 2 weeks or until 24 hours after the last methylene blue dose, whichever comes first.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Phenelzine, Rasagiline. The full list is on the Desvenlafaxine page.
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