Interazioni tra farmaci
Desvenlafaxine + Safinamide
Gravità: Controindicata
Desvenlafaxine and Safinamide: contraindicated interaction.
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Sintesi
Safinamide inhibits monoamine oxidase and so reduces serotonin breakdown, while desvenlafaxine blocks serotonin and norepinephrine reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal.
Cosa significa questa interazione in parole semplici
Desvenlafaxine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Desvenlafaxine belongs to Central Nervous System; Safinamide belongs to Central Nervous System.
Perché avviene
Additive serotonergic activity: reversible MAO-B inhibition (selectivity is lost at higher doses) plus monoamine reuptake inhibition
Cosa fare
Do not combine; allow at least 14 days after stopping the safinamide before starting desvenlafaxine, and at least 14 days after stopping desvenlafaxine before starting the safinamide.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Controindicata
- Desvenlafaxine + Methylene blue Controindicata
- Desvenlafaxine + Phenelzine Controindicata
- Desvenlafaxine + Rasagiline Controindicata
- Desvenlafaxine + Selegiline Controindicata
- Desvenlafaxine + Selegiline transdermal Controindicata
Altre interazioni di Safinamide
- Amitriptyline + Safinamide Controindicata
- Amoxapine + Safinamide Controindicata
- Amphetamine polistirex + Safinamide Controindicata
- Clomipramine + Safinamide Controindicata
- Cyclobenzaprine + Safinamide Controindicata
- Desipramine + Safinamide Controindicata
Domande frequenti
Can I take Desvenlafaxine with Safinamide?
MediHelp rates the interaction as contraindicated. Desvenlafaxine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Safinamide inhibits monoamine oxidase and so reduces serotonin breakdown, while desvenlafaxine blocks serotonin and norepinephrine reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal.
How serious is the interaction between Desvenlafaxine and Safinamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; allow at least 14 days after stopping the safinamide before starting desvenlafaxine, and at least 14 days after stopping desvenlafaxine before starting the safinamide.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Desvenlafaxine page.
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