Interazioni tra farmaci
Desvenlafaxine + Selegiline transdermal
Gravità: Controindicata
Desvenlafaxine and Selegiline transdermal: contraindicated interaction.
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Sintesi
Transdermal selegiline provides irreversible MAO inhibition, and with desvenlafaxine it can cause serotonin syndrome and hypertensive crisis. The combination can be life-threatening.
Cosa significa questa interazione in parole semplici
Desvenlafaxine and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Irreversible MAO inhibition combined with serotonin and norepinephrine reuptake inhibition produces excess monoamine activity.
Cosa fare
Do not co-administer. Wait at least 14 days after stopping selegiline before starting desvenlafaxine, and at least 7 days after stopping desvenlafaxine before starting selegiline.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Controindicata
- Desvenlafaxine + Methylene blue Controindicata
- Desvenlafaxine + Phenelzine Controindicata
- Desvenlafaxine + Rasagiline Controindicata
- Desvenlafaxine + Safinamide Controindicata
- Desvenlafaxine + Selegiline Controindicata
Domande frequenti
Can I take Desvenlafaxine with Selegiline transdermal?
MediHelp rates the interaction as contraindicated. Desvenlafaxine and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Transdermal selegiline provides irreversible MAO inhibition, and with desvenlafaxine it can cause serotonin syndrome and hypertensive crisis. The combination can be life-threatening.
How serious is the interaction between Desvenlafaxine and Selegiline transdermal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Wait at least 14 days after stopping selegiline before starting desvenlafaxine, and at least 7 days after stopping desvenlafaxine before starting selegiline.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Desvenlafaxine page.
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