Interazioni tra farmaci
Dexamethasone + Mifepristone
Gravità: Controindicata
Dexamethasone and Mifepristone: contraindicated interaction.
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Sintesi
Mifepristone is a glucocorticoid receptor antagonist, so it can block the effect of dexamethasone and precipitate adrenal insufficiency in patients who depend on corticosteroid therapy. Reduced corticosteroid effect may also worsen the underlying condition being treated.
Cosa significa questa interazione in parole semplici
Dexamethasone and Mifepristone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dexamethasone belongs to Endocrine; Mifepristone belongs to Endocrine.
Perché avviene
Glucocorticoid receptor antagonism by mifepristone opposes corticosteroid effect
Cosa fare
Mifepristone labelling contraindicates it in patients on long-term corticosteroids; avoid, or use an alternative route and monitor for adrenal insufficiency symptoms.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Dexamethasone
- Bcg vaccine live + Dexamethasone Controindicata
- Dexamethasone + Rilpivirine Controindicata
- Dexamethasone + Smallpox vaccine live Controindicata
- Dexamethasone + Varicella virus vaccine live Controindicata
- Dexamethasone + Yellow fever vaccine Controindicata
- Dexamethasone + Zoster vaccine live Controindicata
Altre interazioni di Mifepristone
- Apixaban + Mifepristone Controindicata
- Argatroban + Mifepristone Controindicata
- Cisapride + Mifepristone Controindicata
- Cortisone + Mifepristone Controindicata
- Cyclosporin + Mifepristone Controindicata
- Dabigatran etexilate + Mifepristone Controindicata
Domande frequenti
Can I take Dexamethasone with Mifepristone?
MediHelp rates the interaction as contraindicated. Dexamethasone and Mifepristone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Mifepristone is a glucocorticoid receptor antagonist, so it can block the effect of dexamethasone and precipitate adrenal insufficiency in patients who depend on corticosteroid therapy. Reduced corticosteroid effect may also worsen the underlying condition being treated.
How serious is the interaction between Dexamethasone and Mifepristone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Mifepristone labelling contraindicates it in patients on long-term corticosteroids; avoid, or use an alternative route and monitor for adrenal insufficiency symptoms.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Rilpivirine, Smallpox vaccine live. The full list is on the Dexamethasone page.
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