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Interazioni tra farmaci

Dicloxacillin + Methotrexate

Gravità: Moderata

Dicloxacillin and Methotrexate: moderate interaction.

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Sintesi

Penicillins can raise methotrexate blood levels and prolong its exposure. This may lead to bone marrow suppression and gastrointestinal toxicity, particularly with high-dose methotrexate or reduced kidney function.

Cosa significa questa interazione in parole semplici

Dicloxacillin and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Dicloxacillin belongs to Anti Bacterial; Methotrexate belongs to Oncology.

Livello di evidenza: Moderate

Perché avviene

Penicillins compete with methotrexate for renal tubular secretion, reducing its renal clearance.

Cosa fare

Monitor blood counts, renal function and methotrexate levels where available. Consider an alternative antibiotic or reduce methotrexate dose if toxicity develops.

Cosa chiedere al farmacista

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Dicloxacillin with Methotrexate?

MediHelp rates the interaction as moderate. Dicloxacillin and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Penicillins can raise methotrexate blood levels and prolong its exposure. This may lead to bone marrow suppression and gastrointestinal toxicity, particularly with high-dose methotrexate or reduced kidney function.

How serious is the interaction between Dicloxacillin and Methotrexate?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, renal function and methotrexate levels where available. Consider an alternative antibiotic or reduce methotrexate dose if toxicity develops.

What other medicines interact with Methotrexate?

MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.

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