Interazioni tra farmaci
Ketorolac + Methotrexate
Gravità: Controindicata
Ketorolac and Methotrexate: contraindicated interaction.
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Sintesi
Ketorolac can sharply increase methotrexate exposure and impair renal function, leading to severe myelosuppression, mucositis and renal injury, particularly with high-dose methotrexate.
Cosa significa questa interazione in parole semplici
Ketorolac and Methotrexate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ketorolac belongs to Musculoskeletal; Methotrexate belongs to Oncology.
Perché avviene
Reduced renal tubular secretion of methotrexate combined with ketorolac-induced reduction in renal perfusion.
Cosa fare
Do not combine ketorolac with high-dose methotrexate and use a non-NSAID analgesic instead. Avoid it with low-dose methotrexate where possible, particularly in renal impairment.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Methotrexate
- Acitretin + Methotrexate Controindicata
- Adenovirus types 4 and 7 live + Methotrexate Controindicata
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Controindicata
- Measles mumps and rubella vaccine live + Methotrexate Controindicata
- Measles mumps and rubella vaccine + Methotrexate Controindicata
- Measles mumps rubella and varicella vaccine live + Methotrexate Controindicata
Altre interazioni di Ketorolac
- Aceclofenac + Ketorolac Controindicata
- Acemetacin + Ketorolac Controindicata
- Acetylsalicylic acid + Ketorolac Controindicata
- Apixaban + Ketorolac Controindicata
- Argatroban + Ketorolac Controindicata
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Controindicata
Domande frequenti
Can I take Ketorolac with Methotrexate?
MediHelp rates the interaction as contraindicated. Ketorolac and Methotrexate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketorolac can sharply increase methotrexate exposure and impair renal function, leading to severe myelosuppression, mucositis and renal injury, particularly with high-dose methotrexate.
How serious is the interaction between Ketorolac and Methotrexate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine ketorolac with high-dose methotrexate and use a non-NSAID analgesic instead. Avoid it with low-dose methotrexate where possible, particularly in renal impairment.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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