Interazioni tra farmaci
Measles mumps and rubella vaccine + Methotrexate
Gravità: Controindicata
Measles mumps and rubella vaccine and Methotrexate: contraindicated interaction.
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Sintesi
Methotrexate suppresses cellular and humoral immunity, so a live attenuated vaccine may produce a weaker antibody response. The vaccine viruses may also replicate unchecked, which raises the risk of disseminated vaccine-strain infection. Low-dose methotrexate carries less risk than high-dose regimens, but live vaccines remain generally avoided.
Cosa significa questa interazione in parole semplici
Measles mumps and rubella vaccine and Methotrexate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Measles mumps and rubella vaccine belongs to Miscellaneous; Methotrexate belongs to Oncology.
Perché avviene
Antimetabolite-induced immunosuppression impairs the immune response to live attenuated virus and permits vaccine virus replication.
Cosa fare
Give live vaccines at least 4 weeks before starting methotrexate where possible, and avoid them during treatment. After stopping, wait about 3 months or until immune recovery is confirmed; specialist review is needed for low-dose cases.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Controindicata
- Anakinra + Measles mumps and rubella vaccine Controindicata
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Controindicata
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Controindicata
- Azathioprine + Measles mumps and rubella vaccine Controindicata
- Basiliximab + Measles mumps and rubella vaccine Controindicata
Altre interazioni di Methotrexate
- Acitretin + Methotrexate Controindicata
- Adenovirus types 4 and 7 live + Methotrexate Controindicata
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Controindicata
- Ketorolac + Methotrexate Controindicata
- Measles mumps and rubella vaccine live + Methotrexate Controindicata
- Measles mumps rubella and varicella vaccine live + Methotrexate Controindicata
Domande frequenti
Can I take Measles mumps and rubella vaccine with Methotrexate?
MediHelp rates the interaction as contraindicated. Measles mumps and rubella vaccine and Methotrexate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Methotrexate suppresses cellular and humoral immunity, so a live attenuated vaccine may produce a weaker antibody response. The vaccine viruses may also replicate unchecked, which raises the risk of disseminated vaccine-strain infection. Low-dose methotrexate carries less risk than high-dose regimens, but live vaccines remain generally avoided.
How serious is the interaction between Measles mumps and rubella vaccine and Methotrexate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give live vaccines at least 4 weeks before starting methotrexate where possible, and avoid them during treatment. After stopping, wait about 3 months or until immune recovery is confirmed; specialist review is needed for low-dose cases.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
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