Interazioni tra farmaci
Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df
Gravità: Controindicata
Didanosine and Elvitegravir / cobicistat / emtricitabine / tenofovir df: contraindicated interaction.
Ultimo aggiornamento
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Sintesi
This fixed-dose product is a complete HIV regimen and is not intended for use with other antiretrovirals. Tenofovir also raises didanosine exposure, increasing risks of pancreatitis, neuropathy and lactic acidosis, and can blunt CD4 recovery.
Cosa significa questa interazione in parole semplici
Didanosine and Elvitegravir / cobicistat / emtricitabine / tenofovir df are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Tenofovir increases didanosine concentrations, with additive mitochondrial toxicity and duplicate nucleoside therapy.
Cosa fare
Do not co-administer; stop didanosine if the single-tablet regimen is used and select an alternative regimen if didanosine is essential.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Didanosine
- Didanosine + Hydroxycarbamide Controindicata
- Didanosine + Hydroxyurea Controindicata
- Didanosine + Ribavirin Controindicata
- Didanosine + Stavudine Controindicata
- Allopurinol + Didanosine Maggiore
- Atidarsagene autotemcel + Didanosine Maggiore
Domande frequenti
Can I take Didanosine with Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates the interaction as contraindicated. Didanosine and Elvitegravir / cobicistat / emtricitabine / tenofovir df are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. This fixed-dose product is a complete HIV regimen and is not intended for use with other antiretrovirals. Tenofovir also raises didanosine exposure, increasing risks of pancreatitis, neuropathy and lactic acidosis, and can blunt CD4 recovery.
How serious is the interaction between Didanosine and Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; stop didanosine if the single-tablet regimen is used and select an alternative regimen if didanosine is essential.
What other medicines interact with Didanosine?
MediHelp also lists interactions of Didanosine with, for example, Hydroxycarbamide, Hydroxyurea, Ribavirin. The full list is on the Didanosine page.
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