Interazioni tra farmaci
Didanosine + Hydroxycarbamide
Gravità: Controindicata
Didanosine and Hydroxycarbamide: contraindicated interaction.
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Sintesi
Combining hydroxycarbamide with didanosine has been associated with pancreatitis, hepatotoxicity and peripheral neuropathy, some fatal. The combination also appears to worsen immunologic outcomes in HIV.
Cosa significa questa interazione in parole semplici
Didanosine and Hydroxycarbamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Didanosine belongs to Anti Virals; Hydroxycarbamide belongs to Oncology.
Perché avviene
Overlapping toxicities, with hydroxycarbamide possibly increasing didanosine active metabolite activity and mitochondrial toxicity.
Cosa fare
Avoid the combination and use alternative antiretrovirals without these toxicities. Monitor lipase, liver enzymes and neurologic symptoms if prior exposure occurred.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Hydroxycarbamide
- Hydroxycarbamide + Stavudine Controindicata
Altre interazioni di Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Controindicata
- Didanosine + Hydroxyurea Controindicata
- Didanosine + Ribavirin Controindicata
- Didanosine + Stavudine Controindicata
- Allopurinol + Didanosine Maggiore
- Atidarsagene autotemcel + Didanosine Maggiore
Domande frequenti
Can I take Didanosine with Hydroxycarbamide?
MediHelp rates the interaction as contraindicated. Didanosine and Hydroxycarbamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining hydroxycarbamide with didanosine has been associated with pancreatitis, hepatotoxicity and peripheral neuropathy, some fatal. The combination also appears to worsen immunologic outcomes in HIV.
How serious is the interaction between Didanosine and Hydroxycarbamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use alternative antiretrovirals without these toxicities. Monitor lipase, liver enzymes and neurologic symptoms if prior exposure occurred.
What other medicines interact with Hydroxycarbamide?
MediHelp also lists interactions of Hydroxycarbamide with, for example, Stavudine. The full list is on the Hydroxycarbamide page.
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