Interazioni tra farmaci
Didanosine + Hydroxyurea
Gravità: Controindicata
Didanosine and Hydroxyurea: contraindicated interaction.
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Sintesi
Hydroxyurea combined with didanosine has caused pancreatitis, hepatotoxicity including fatal hepatic failure, and peripheral neuropathy in HIV patients. The overlapping toxicities make the combination dangerous.
Cosa significa questa interazione in parole semplici
Didanosine and Hydroxyurea are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Didanosine belongs to Anti Virals; Hydroxyurea belongs to Miscellaneous.
Perché avviene
Additive pancreatic, hepatic and neurotoxicity; the exact mechanism is not fully established.
Cosa fare
Do not combine; choose a different antiretroviral. If exposure has occurred, monitor for pancreatitis, liver injury and neuropathy and stop the agents if signs appear.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Controindicata
- Didanosine + Hydroxycarbamide Controindicata
- Didanosine + Ribavirin Controindicata
- Didanosine + Stavudine Controindicata
- Allopurinol + Didanosine Maggiore
- Atidarsagene autotemcel + Didanosine Maggiore
Altre interazioni di Hydroxyurea
Domande frequenti
Can I take Didanosine with Hydroxyurea?
MediHelp rates the interaction as contraindicated. Didanosine and Hydroxyurea are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Hydroxyurea combined with didanosine has caused pancreatitis, hepatotoxicity including fatal hepatic failure, and peripheral neuropathy in HIV patients. The overlapping toxicities make the combination dangerous.
How serious is the interaction between Didanosine and Hydroxyurea?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; choose a different antiretroviral. If exposure has occurred, monitor for pancreatitis, liver injury and neuropathy and stop the agents if signs appear.
What other medicines interact with Didanosine?
MediHelp also lists interactions of Didanosine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Hydroxycarbamide, Ribavirin. The full list is on the Didanosine page.
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