Interazioni tra farmaci
Digoxin + Torsemide
Gravità: Maggiore
Digoxin and Torsemide: major interaction.
Ultimo aggiornamento Fonti: US FDA label
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Sintesi
Loop diuretics can cause hypokalemia and hypomagnesemia, which sensitise the myocardium to digoxin and increase the risk of toxicity and ventricular arrhythmias. The interaction is well documented and clinically important, especially in older patients and those with renal impairment. Digoxin concentrations themselves are not usually changed.
Cosa significa questa interazione in parole semplici
Digoxin and Torsemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Digoxin belongs to Cardiovascular; Torsemide belongs to Cardiovascular.
Perché avviene
Pharmacodynamic: diuretic-induced potassium and magnesium depletion increases digoxin binding to Na+/K+-ATPase and enhances its arrhythmogenic effects.
Cosa fare
Monitor serum potassium and magnesium regularly, keeping potassium in the normal to high-normal range. Supplement electrolytes or add a potassium-sparing agent if needed.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Riferimenti
Altre interazioni di Torsemide
- Amikacin + Torsemide Maggiore
- Amiodarone + Torsemide Maggiore
- Carbenoxolone + Torsemide Maggiore
- Chlorthalidone + Torsemide Maggiore
- Dexamethasone-tobramycin + Torsemide Maggiore
- Ethacrynic acid + Torsemide Maggiore
Altre interazioni di Digoxin
- Digoxin + Lily of the valley Controindicata
- Digoxin + Squill Controindicata
- Adagrasib + Digoxin Maggiore
- Amiodarone + Digoxin Maggiore
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Maggiore
- Amphotericin b deoxycholate + Digoxin Maggiore
Domande frequenti
Can I take Digoxin with Torsemide?
MediHelp rates the interaction as major. Digoxin and Torsemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Loop diuretics can cause hypokalemia and hypomagnesemia, which sensitise the myocardium to digoxin and increase the risk of toxicity and ventricular arrhythmias. The interaction is well documented and clinically important, especially in older patients and those with renal impairment. Digoxin concentrations themselves are not usually changed.
How serious is the interaction between Digoxin and Torsemide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium regularly, keeping potassium in the normal to high-normal range. Supplement electrolytes or add a potassium-sparing agent if needed.
What other medicines interact with Torsemide?
MediHelp also lists interactions of Torsemide with, for example, Amikacin, Amiodarone, Carbenoxolone. The full list is on the Torsemide page.
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