Interazioni tra farmaci
Disopyramide + Itraconazole
Gravità: Controindicata
Disopyramide and Itraconazole: contraindicated interaction.
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Sintesi
Itraconazole raises disopyramide concentrations and both drugs prolong the QT interval. This can cause torsades de pointes and other serious arrhythmias, as well as anticholinergic and hypoglycemic effects from high disopyramide levels.
Cosa significa questa interazione in parole semplici
Disopyramide and Itraconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Disopyramide belongs to Cardiovascular; Itraconazole belongs to Anti Fungals.
Perché avviene
CYP3A4 inhibition raises disopyramide levels, with additive QT prolongation.
Cosa fare
Avoid the combination. Use a non-interacting antiarrhythmic or an antifungal without CYP3A4 inhibition.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Itraconazole
- Alfuzosin + Itraconazole Controindicata
- Alprazolam + Itraconazole Controindicata
- Avanafil + Itraconazole Controindicata
- Conivaptan + Itraconazole Controindicata
- Dihydroergotamine intranasal + Itraconazole Controindicata
- Dihydroergotamine + Itraconazole Controindicata
Altre interazioni di Disopyramide
- Amisulpride + Disopyramide Controindicata
- Desipramine + Disopyramide Controindicata
- Disopyramide + Dronedarone Controindicata
- Disopyramide + Ketoconazole Controindicata
- Disopyramide + Maprotiline Controindicata
- Disopyramide + Moxifloxacin Controindicata
Domande frequenti
Can I take Disopyramide with Itraconazole?
MediHelp rates the interaction as contraindicated. Disopyramide and Itraconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Itraconazole raises disopyramide concentrations and both drugs prolong the QT interval. This can cause torsades de pointes and other serious arrhythmias, as well as anticholinergic and hypoglycemic effects from high disopyramide levels.
How serious is the interaction between Disopyramide and Itraconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Use a non-interacting antiarrhythmic or an antifungal without CYP3A4 inhibition.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
