Interazioni tra farmaci
Dihydroergotamine intranasal + Voriconazole
Gravità: Controindicata
Dihydroergotamine intranasal and Voriconazole: contraindicated interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Voriconazole raises systemic dihydroergotamine exposure from the nasal route and risks ergotism with severe vasospasm and ischemia.
Cosa significa questa interazione in parole semplici
Dihydroergotamine intranasal and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Strong CYP3A4 inhibition by voriconazole reduces dihydroergotamine clearance.
Cosa fare
Do not use together; use a non-ergot acute migraine treatment such as a triptan not affected by CYP3A4 inhibition.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Dihydroergotamine intranasal e Voriconazole, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Altre interazioni di Voriconazole
- Avanafil + Voriconazole Controindicata
- Butabarbital + Voriconazole Controindicata
- Carbamazepine + Voriconazole Controindicata
- Conivaptan + Voriconazole Controindicata
- Dihydroergotamine + Voriconazole Controindicata
- Dofetilide + Voriconazole Controindicata
Domande frequenti
Can I take Dihydroergotamine intranasal with Voriconazole?
MediHelp rates the interaction as contraindicated. Dihydroergotamine intranasal and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Voriconazole raises systemic dihydroergotamine exposure from the nasal route and risks ergotism with severe vasospasm and ischemia.
How serious is the interaction between Dihydroergotamine intranasal and Voriconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; use a non-ergot acute migraine treatment such as a triptan not affected by CYP3A4 inhibition.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
