Interazioni tra farmaci
Disopyramide + Sotalol
Gravità: Controindicata
Disopyramide and Sotalol: contraindicated interaction.
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Sintesi
Both agents prolong repolarization, and disopyramide also has negative inotropic effects. Combined use substantially raises the risk of torsades de pointes and heart failure worsening.
Cosa significa questa interazione in parole semplici
Disopyramide and Sotalol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Disopyramide belongs to Cardiovascular; Sotalol belongs to Cardiovascular.
Perché avviene
Additive QT prolongation and additive negative inotropic effect.
Cosa fare
Avoid combining class Ia and class III antiarrhythmics; choose one agent and monitor ECG closely during any transition.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Sotalol
- Arsenic trioxide + Sotalol Controindicata
- Artemether / lumefantrine + Sotalol Controindicata
- Dofetilide + Sotalol Controindicata
- Dronedarone + Sotalol Controindicata
- Droperidol + Sotalol Controindicata
- Eliglustat + Sotalol Controindicata
Altre interazioni di Disopyramide
- Amisulpride + Disopyramide Controindicata
- Desipramine + Disopyramide Controindicata
- Disopyramide + Dronedarone Controindicata
- Disopyramide + Itraconazole Controindicata
- Disopyramide + Ketoconazole Controindicata
- Disopyramide + Maprotiline Controindicata
Domande frequenti
Can I take Disopyramide with Sotalol?
MediHelp rates the interaction as contraindicated. Disopyramide and Sotalol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both agents prolong repolarization, and disopyramide also has negative inotropic effects. Combined use substantially raises the risk of torsades de pointes and heart failure worsening.
How serious is the interaction between Disopyramide and Sotalol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining class Ia and class III antiarrhythmics; choose one agent and monitor ECG closely during any transition.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Dofetilide. The full list is on the Sotalol page.
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