Interazioni tra farmaci
Dolasetron + Ziprasidone
Gravità: Controindicata
Dolasetron and Ziprasidone: contraindicated interaction.
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Sintesi
Ziprasidone is among the antipsychotics with notable QT prolongation, and it is contraindicated with other QT-prolonging drugs. Combined with dolasetron the risk of torsades de pointes is increased.
Cosa significa questa interazione in parole semplici
Dolasetron and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dolasetron belongs to Gastrointestinal Tract; Ziprasidone belongs to Central Nervous System.
Perché avviene
Additive blockade of cardiac repolarizing potassium currents causing QT prolongation.
Cosa fare
Avoid the combination and use an antiemetic without QT effect. If an antiemetic is essential, consider a different agent and monitor ECG and electrolytes.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Dolasetron
- Apomorphine + Dolasetron Controindicata
- Dofetilide + Dolasetron Controindicata
- Dolasetron + Ibutilide Controindicata
- Dolasetron + Pimozide Controindicata
- Dolasetron + Thioridazine Controindicata
- Dolasetron + Vandetanib Controindicata
Altre interazioni di Ziprasidone
- Amiodarone + Ziprasidone Controindicata
- Amitriptyline + Ziprasidone Controindicata
- Arsenic trioxide + Ziprasidone Controindicata
- Bedaquiline + Ziprasidone Controindicata
- Chloroquine + Ziprasidone Controindicata
- Citalopram + Ziprasidone Controindicata
Domande frequenti
Can I take Dolasetron with Ziprasidone?
MediHelp rates the interaction as contraindicated. Dolasetron and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ziprasidone is among the antipsychotics with notable QT prolongation, and it is contraindicated with other QT-prolonging drugs. Combined with dolasetron the risk of torsades de pointes is increased.
How serious is the interaction between Dolasetron and Ziprasidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an antiemetic without QT effect. If an antiemetic is essential, consider a different agent and monitor ECG and electrolytes.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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